Benzodiazepines

Properties of Benzodiazepines

•  Benzodiazepines increase the affinity of the receptor for GABA, and thus increase Cl­- conductance and hyperpolarizing current.
• Therefore, benzodiazepines are indirect agonists of the GABA receptor.

Medical Uses of Benzodiazepines

• Anxiolytic – chronic / phobic anxiety & panic attacks.
• Sedative and hypnotic – sleep disturbance & anaesthesia / premed.
• Anticonvulsant – status epilepticus, myoclonic & photic epilepsy.
• Muscle relaxant – muscle spasm / spasticity.
• Alcohol withdrawal.