Description

Clonazolam (also known as Clonitrazolam) is a novel depressant substance of the benzodiazepine chemical class. It produces anxiolytic, sedative, muscle relaxant and amnesic effects when administered. This compound is a novel research chemical derivative of the FDA-approved drugs clonazepam (Klonopin, Rivitrol) and alprazolam (Xanax). Clonazolam is reported to be roughly 2.5x as potent as alprazolam.

The synthesis of clonazolam was first reported in 1971. It is described as the most active compound in the series tested. Clonazolam is reputed to be highly potent and concerns have been raised that together with  flubromazolam they may pose comparatively higher risks than other designer benzodiazepines. This is due to their ability to produce strong sedation and amnesia at oral doses as low as 0.5 mg, or 500 micrograms (ug). It is reported to have a medium-length onset of action (20 – 60 minutes).