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Methylisopropyllysergamide (lysergic acid methylisopropyl amide, MIPLA) is an analogue of LSD. It was originally discovered by Albert Hofmann at Sandoz. MIPLA lysergamide was discovered during the original structure-activity research into LSD. MIPLA has subsequently been investigated in more detail by the team led by David E. Nichols at Purdue University. Methylisopropyllysergamide is a structural isomer of LSD. However, the alkyl groups on the amide nitrogen having been subjected to a methylene shuffle.
MIPLA (Methylisopropyllysergamide) and its ethylisopropyl homologue are the only simple N,N-dialkyl lysergamides that approach the potency of LSD itself. They are around 1/3-1/2 the potency of LSD,while all other dialkyl analogues tested are only around 1/10 as potent as LSD.
sec-butyl and t-butyl derivatives(N-monoalkyl lysergamides) were also found to show an activity profile and potency comparable to LSD. The mono-isopropyl derivative is only slightly weaker than MIPLA. Apart from its lower potency, the hallucinogenic effects of methylisopropyllysergamide are similar to those of LSD itself. Furthermore, the main use for this drug is in the studies of the binding site at the 5-HT2A receptor. Thus, LSD exerts most of its pharmacological effects.
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